Synthesis and biological activity of novel zingerone-thiohydantoin hybrids
نویسندگان
چکیده
A series of zingerone?thiohydantoin hybrids were synthesized from O-alkyl zingerone derivatives by cyclocondensation with thiosemicarbazide in a two-step reaction. The obtained new potentially bioactive compounds structurally characterized IR and NMR spectroscopy, as well elemental HRMS analysis. In addition, their antimicrobial vitro anticancer activities tested. tested showed low to moderate activity. Zingerone?thiohydantoin hybrid an O-butyl substituent exerted the significant cytotoxic activity on colon HCT-116 cancer cells, without toxicity healthy MRC-5 cells.
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ژورنال
عنوان ژورنال: Journal of The Serbian Chemical Society
سال: 2022
ISSN: ['1820-7421', '0352-5139']
DOI: https://doi.org/10.2298/jsc220404047v